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Original title:
Relationship between in-vivo [11C]PiB PET Signal and Amyloid-β Plaque Pathology in different transgenic Mouse Models of Alzheimer's Disease
Translated title:
Verhältnis von in-vivo [11C]PiB PET Signal und Amyloid-β Plaque-Pathology in verschiedenen transgenen Mausmodellen der Alzheimer Krankheit
Author:
von Reutern, Boris Gerhard Jaroslav
Year:
2012
Document type:
Dissertation
Faculty/School:
Fakultät für Medizin
Advisor:
Drzezga, Alexander (Prof. Dr.)
Referee:
Ziegler, Sibylle (Prof. Dr.); Beer, Ambros (Priv.-Doz. Dr.); Drzezga, Alexander (Prof. Dr.)
Language:
en
Subject group:
MED Medizin
Keywords:
Amyloid-β, mouse model, transgenic, Alzheimer's disease, positron emission tomography, PET, PiB, Tg2576, ARTE10, APP, PS1, pyroglutamate, statistical parametric mapping, SPM, voxel
Translated keywords:
Amyloid-β, Mausmodell, transgen, Alzheimer Krankheit, positron emissions tomography, PET, PiB, Tg2576, ARTE10, APP, PS1, Pyroglutamat, statistical parametric mapping, SPM, voxel
Abstract:
The quantitative relationship between the in-vivo signal of amyloid-β (Aβ) positron emission tomography (PET) imaging with [11C]6-OH-BTA-1 (PiB) in transgenic mouse models of Alzheimer's disease and the underlying histopathology is so far ill-defined. In this study we compared a single transgenic APP (Tg2576) and a double transgenic APP/PS1 mouse model (ARTE10). We performed PiB PET imaging followed by an automated quantification of Aβ plaque histopathology using three different stainings: Thio...     »
Translated abstract:
Der quantitative Zusammenhang zwischen dem in-vivo Signal der Amyloid-β (Aβ) Bildgebung mittels Positronen-Emissions-Tomographie (PET) mit [11C]6-OH-BTA-1 (PiB) in transgenen Mausmodellen der Alzheimer Erkrankung und der zugrunde liegenden Histopathologie ist bisher nicht ausreichend geklärt. Diese Arbeit vergleicht ein einfach-transgenes APP (Tg2576) und ein doppelt-transgenes APP/PS1 Mausmodell (ARTE10). Nach einem PiB PET-Scan wurde mittels drei histologischer Färbungen die Aβ-Plaque-Patholog...     »
WWW:
https://mediatum.ub.tum.de/?id=1115221
Date of submission:
17.09.2012
Oral examination:
25.09.2012
File size:
2115719 bytes
Pages:
97
Urn (citeable URL):
https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20120925-1115221-1-5
Last change:
29.01.2013
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