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- Author(s):
- Etgen, Thorleif; Chonchol, Michel; Förstl, Hans; Sander, Dirk
- Title:
- Chronic Kidney Disease and Cognitive Impairment: A Systematic Review and Meta-Analysis
- Abstract:
- Background: Chronic kidney disease (CKD) has emerged as a possible new risk factor of cognitive impairment and dementia, but results of studies remain conflicting. Methods: A systematic literature research of electronic databases (MEDLINE, Cochrane Library and Goggle Scholar covering the period from 1980 to January 2012) and meta-analysis of relevant cross-sectional and longitudinal studies were conducted to assess the association of CKD and cognitive decline. Results: Most cross-sectional and longitudinal studies suggest an association between cognitive impairment and CKD. Meta-analysis of cross-sectional and longitudinal studies comprising 54,779 participants yielded an association of cognitive decline in patients with CKD compared with patients without CKD (OR 1.65, 95% CI 1.32–2.05; p < 0.001, and OR 1.39, 95% CI 1.15–1.68; p < 0.001, respectively). Conclusion: This is the first meta-analysis assessing the impact of CKD on cognitive decline. Our results suggest CKD being a significant and independent somatic risk factor in the development of cognitive decline.
- Keywords:
- Dementia; Risk factors; Chronic kidney disease; Cognitive impairment
- Journal title:
- American Journal of Nephrology
- Year:
- 2012
- Journal volume:
- 35
- Journal issue:
- 5
- Pages contribution:
- 474--482
- Fulltext / DOI:
- doi:10.1159/000338135
- Publisher:
- S. Karger AG
- Publisher address:
- Basel, Switzerland
- Print-ISSN:
- 1421-9670
- E-ISSN:
- 1421-9670
- Notes:
- Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
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