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- Document type:
- Zeitschriftenaufsatz
- Author(s):
- Diehl-Schmid, J.; Grimmer, T.; Drzezga, A.; Bornschein, S.; Perneczky, R.; Förstl, H.; Schwaiger, M.; Kurz, A.
- Title:
- Longitudinal Changes of Cerebral Glucose Metabolism in Semantic Dementia
- Abstract:
- Background: Semantic dementia (SD). Objective: To identify the pattern of decline of cerebral glucose metabolism in SD using cerebral 18F-fluoro-2-desoxy-D-glucose positron emission tomography scanning (18F-FDG-PET). Methods: Eight patients with SD underwent 18F-FDG-PET at baseline and at re-examination in average 15 months later. Results: Compared with healthy control subjects, patients with SD showed a significant asymmetrical (left > right) hypometabolism of the temporal lobes, particularly of the anterior poles, at baseline. At follow-up, we observed a deterioration of cognitive abilities. However, in addition to the temporal lobes no other cortical or subcortical region showed a significant reduction of glucose metabolism except the anterior cingulate cortex (pcorr < 0.05). Conclusion: Subtle functional changes suffice to produce significant neuropsycho- logical deterioration.
- Keywords:
- Positron emission tomography; Semantic dementia; Frontotemporal dementia; Follow-up; Glucose metabolism
- Journal title:
- Dementia and Geriatric Cognitive Disorders
- Year:
- 2006
- Journal volume:
- 22
- Journal issue:
- 4
- Pages contribution:
- 346--351
- Fulltext / DOI:
- doi:10.1159/000095624
- Publisher:
- S. Karger AG
- Publisher address:
- Basel, Switzerland
- Print-ISSN:
- 1421-9824
- E-ISSN:
- 1421-9824
- Notes:
- Dieser Beitrag ist mit Zustimmung des Rechteinhabers aufgrund einer (DFG-geförderten) Allianz- bzw. Nationallizenz frei zugänglich. This publication is with permission of the rights owner freely accessible due to an Alliance licence and a national licence (funded by the DFG, German Research Foundation) respectively.
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