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Document type:
journal article
Author(s):
Swirski, FK; Nahrendorf, M; Etzrodt, M; Wildgruber, M; Cortez-Retamozo, V; Panizzi, P; Figueiredo, JL; Kohler, RH; Chudnovskiy, A; Waterman, P; Aikawa, E; Mempel, TR; Libby, P; Weissleder, R; Pittet, MJ
Title:
Identification of splenic reservoir monocytes and their deployment to inflammatory sites.
Abstract:
A current paradigm states that monocytes circulate freely and patrol blood vessels but differentiate irreversibly into dendritic cells (DCs) or macrophages upon tissue entry. Here we show that bona fide undifferentiated monocytes reside in the spleen and outnumber their equivalents in circulation. The reservoir monocytes assemble in clusters in the cords of the subcapsular red pulp and are distinct from macrophages and DCs. In response to ischemic myocardial injury, splenic monocytes increase th...     »
Journal title abbreviation:
Science
Year:
2009
Journal volume:
325
Journal issue:
5940
Pages contribution:
612-6
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/19644120
Print-ISSN:
0036-8075
TUM Institution:
Röntgendiagnostik
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