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- Original title:
- The role of p22phox in the cardiovascular response to obesity
- Translated title:
- Die Rolle von p22phox in der kardiovaskulären Antwort auf Adipositas
- Author:
- Klop, Mathieu Edouard
- Year:
- 2023
- Document type:
- Dissertation
- Faculty/School:
- TUM School of Medicine and Health
- Advisor:
- Görlach, Agnes (Prof. Dr.)
- Referee:
- Görlach, Agnes (Prof. Dr.); Keßler, Thorsten (Priv.-Doz. Dr.)
- Language:
- en
- Subject group:
- MED Medizin
- TUM classification:
- MED 410
- Abstract:
- This study aimed to understand the role of NADPH oxidases in the obese heart. Results showed that p22phox deficient mice, lacking functional NADPH oxidases, were protected against obesity induced cardiomyopathy. The study provides compelling evidence that p22phox dependent NADPH oxidases promote obesity induced cardiomyopathy by dysregulating the micro-RNA transcriptome, oxidative stress pathways, unfolded protein response, and programmed cell death.
- Translated abstract:
- Das Ziel dieser Studie war es, die Rolle von NADPH-Oxidasen in Adipositas assoziierten Herzerkrankungen besser zu verstehen. Die Ergebnisse zeigten, dass p22phox-defiziente Mäuse, vor Adipositas assoziierter Kardiomyopathie geschützt waren. Diese Studie zeigt, dass p22phox-abhängige NADPH-Oxidasen das miRNA Transkriptom, oxidative Stresswege, die ungefaltete Proteinantwort und den programmierten Zelltod dysregulieren und dadurch die Adipositas-induzierte Kardiomyopathie fördern.
- WWW:
- https://mediatum.ub.tum.de/?id=1696267
- Date of submission:
- 17.02.2023
- Oral examination:
- 09.08.2023
- File size:
- 15032295 bytes
- Pages:
- 109
- Urn (citeable URL):
- https://nbn-resolving.de/urn/resolver.pl?urn:nbn:de:bvb:91-diss-20230809-1696267-1-4
- Last change:
- 17.11.2023
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